8 months ago
Contract Type: Fixed Term (12 months)
Hours: Full Time
Closing Date: 27th October 2019
Interview Date: Interviews will be held during the week commencing 25th November 2019
STFC - ISIS - Synthesis of deuterated natural products - Industrial Placement
STFC is one of nine organisations that have been brought together to create UK Research and Innovation (UKRI); a new organisation with a vision to ensure the UK maintains its world-leading position in research and innovation.
Each year we offer opportunities to undergraduate students to gain practical experience, working alongside technical experts at the forefront of scientific research. We offer an invaluable experience with exposure to world class science and technology, and the opportunity to develop working relationships that continue well after your placement has finished.
STFC consists of several distinct departments which each focus on a different specialism within science, technology, innovation and support, yet work together to achieve STFC’s grand ambitions. Different departments may look for placement students with similar skills, so you should consider which role/s are most suitable to you, and apply for up to two of these. See all of our current Industrial Placements here.
The ISIS pulsed neutron and muon source at the Rutherford Appleton Laboratory in Oxfordshire is a world-leading centre for research in the physical and life sciences. Based within the ISIS, the ISIS Deuteration Facility is a synthetic chemistry group that synthesise deuterated materials for the ISIS user community. The materials requested are wide ranging, so the synthetic skills of the team are varied. The laboratory has awide range of synthetic and analytical equipment.
Please look here for more information on the support laboratories and the deuteration facility:
Summary of Key Duties
This is an organic synthetic project focused on developing and optimising chemical deuteration methods. It will be entirely lab based, working in the main deuteration laboratory. The lab has an established track record of providing certain classes of chemical compound (e.g. surfactants, fatty acids etc.) but the dynamic nature of the ISIS User Programme means that new requests for isotopic materials can be far wider ranging, and beyond any current established programmes of work within the group.
This project will establish synthetic routes to compounds not routinely provided by the deuteration facility. Specifically isotopically labelled natural products (eg phytantriol, cholesterol) and drug molecules (eg ibuprofen, disulfiram and lidocaine). Your work will follow standard practices in the lab, developing and optimising synthetic procedures where appropriate, performing analysis of reaction outcomes and product purity by standard analytical techniques such as NMR and Mass Spectroscopy, and conforming to health and safety requirements through writing and assessing your own activities through COSHH assessment.
Based in the ISIS Deuteration Facility the project will firstly be focussed developing synthetic routes to commonly requested materials. This will then be adapted to create deuteration versions of these materials. Owing to the complex nature of some requests, selectively deuterated compounds will also need to be synthesised. You will be responsible for the day to day running of your project, maintaining laboratory notebooks and associated COSHH and risk assessments. This is a synthetic project and will involve general techniques for reactions, workups and purification. You will also be responsible for analysing the outcome of your reactions with standard analytical equipment (NMR, IR, GCMS, LCMS).
Knowledge, Skills and Experience
Ideally you will have some experience of synthetic practical’s as part of your university degree, with some knowledge of COSHH and risk assessments. A working understanding of NMR and Mass Spectroscopy would be advantageous, but not essential.
You should be enthusiastic and keen to learn new techniques. Whilst some of this project is known, the later work will require method development so the ability to adapt to a changing work plan is essential.
UK Research and Innovation is a new entity that brings together nine partners to create an independent organisation with a strong voice for research and innovation, and a vision to ensure the UK maintains its world-leading position in research and innovation.
The Science and Technology Facilities Council is a world-leading multi-disciplinary science organisation, and our goal is to deliver economic, societal, scientific and international benefits to the UK and its people – and more broadly to the world.
Criteria to be assessedat Shortlisting (S), Interview (I) or both (S&I)
* At university, enrolled on an undergraduate degree course and required or have requested to take a year out of studies to gain experience within industry (S)
* Right to live and work in the UK (S)
* Registered on a university course currently averaging a 2:1 or higher (S)
* Organic and synthetic laboratory experience (S&I)
* Experience with standard purification techniques eg distillation, chromatography (S&I)
* Familiar with COSHH and risk assessments (S&I)
* Good organisational skills (I)
* Willingness to learn new skills, both technical and non-technical. (S&I)
* Grade A/B at Chemistry A’level, and A’levels in Maths, physics or biology (S)
* Experience with analysing reaction outcome, eg NMR, LCMS, GCMS (S&I)
* Laboratory experience outside of degree classes (S&I)
* Knowledge of good laboratory practice gained from previous laboratory experience (S&I)
* Experience with chemical databases, eg Scifinder, Reaxys, Web of Science (S)
* Ability to prioritise work load (I)
* Good attention to detail and a high degree of accuracy (S&I)
* Ability to adapt to a changing working environment. (I)
* This role will require working in a classified radiation area.
UKRI supports research in areas that include animal health, agriculture and food security, and bioscience for health which includes research on animals, genetic modification and stem cell research. Whilst you may not have direct involvement in this type of research, you should consider whether this conflicts with your personal values or beliefs.
To enable us to hire the very best people we will conduct a full and comprehensive pre-employment check as an essential part of the recruitment process on all individuals that are offered a position with UKRI. This will include a security check and an extreme organisations affiliation check.
UK Research and Innovation recognises and values employees as individuals and aim to provide a pay and rewards package that motivates staff to perform to the best of their ability. The reward package includes a flexible working scheme, a Career Average Revalued Earnings pension scheme, 30 days annual leave allowance and a number of other benefits.
We are committed to developing employees in their roles throughout their career. Learning and development plans enable employees to continue their professional development through training and development opportunities such as e-learning, classroom training and on-the-job experiences. We encourage our employees to share their learning across teams and organisations.
We strive to make decisions based on individual merit and ability. We welcome applications from all sections of the community and promote equality of opportunity in accordance with the Equality Act 2010. As holders of Disability Confident Employer status, we guarantee to interview all applicants with disabilities who meet the minimum criteria for the vacancy.
To apply please download the application form and save it to your pc. You must upload a CV and completed copy of the application form. Please save include the IRC reference number and your name in the filename of all documents uploaded to your application.
Please right click on this link and select ‘save target as' to save the application form to your desktop .
STFC Industrial Placement Application form
To be eligible you must be studying a recognised degree that requires you to undertake an Industrial Placement or have permission from your University to take a year out of your studies to undertake a placement. You must also have the right to work in the UK.
You can apply for up to two Sandwich student placements; You will only need to complete ONE application form. However please ensure that you upload the application form to all applications and ensure the relevant reference number (e.g. IRC205817) is included the filename of each document that you upload.
Closing date: 27th October 2019
Interview/assessment date: 25th – 28th of November 2019
As this job does not fulfil the Home Office Code of Practice criterion for obtaining sponsored migrant worker status we will be unable to apply for sponsorship for anyone not eligible to work in the UK. At interview, all shortlisted candidates are required to bring with them identification documents and original documents that prove they hold or can obtain the right to work in the UK.
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